Appearance: White Fine Powder
CAS Number: 51352-87-5
Molecular Formula: C18H22ClNO2
Test Method: HPLC
PRL-8-53 is a nootropic research compound first synthesized in the 1970’s by Dr Nikolaus Hansl while working at Creighton University,he single study involving humans showed PRL-8-53 improved word recollection scores both 24 and 96 hours after initial memorization. Given the low amount of evidence available for this nootropic, we thought it relevant to reference a journal article in which the creator discusses the compound and numerous other human trials it was used in
1. Prl-8-53 can Enhance cognition and memory formation
2. Prl-8-53 can Anxiolytic properties
3. Prl-8-53 can Anti-depressive effect
4. Prl-8-53 can Treatment of Alzheimer's and
5. Prl-8-53 can Increase coordination
6. Prl-8-53 can Improves mood
7. Prl-8-53 can Help fight fatigue
8. Prl-8-53 can Prevent oxidation within the brain
9. Prl-8-53 can Treat alcohol related brain damage
10. Prl-8-53 can Prevent caffeine withdrawal symptoms
The older subjects in the only human study on PRL-8-53 demonstrated significant improvements in memory after taking a single 5 mg dose. The double-blind study used word memorization as a measure, testing the participants' ability to recall a list of 12 one-syllable words, first to establish a baseline and then again after ingesting PRL-8-53 or a placebo. The subjects were tested on their ability to recall the words 24 hours after hearing them and then again one week later.
The study results indicate that participants who had higher baseline scores showed the least improvement after ingesting PRL-8-53, while subjects who had demonstrated poorer initial memory or who were over 30 years of age showed significant improvement in recall. In an article on the test, Hansl described the effect on the older participants as follows:
"This group was age 30 or older. As might be expected, rote memory did not come as easily to this group as it did to the younger students. The average retention after 24 hours when on placebo was just under three words out of a possible 12. The average retention after one week was two words. However, the same subjects, when learning subsequent to drug administration, retained an average of 5.85 words after 24 hours and 5.25 words after one week. Again the increases were statistically significant. The improvement expressed in percent of placebo performance was 108% for the 24 hour test and 152% for the one-week recall."
Many individual nootropic users who have tried PRL-8-53 confirm its memory-boosting effects, in some cases comparing it to a more powerful version of other nootropics such as nefiracetam and Noopept.
Alpha GPC(Choline Alfoscerato)
Tianeptine sodium salt
Tianeptine free acid