Nootropics CAS 1270138-40-3 White Powder NSI-189

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Company Information

Wuhan Hengheda Pharm Co., Ltd.

CN Manufacturer
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<24h
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90.7%
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Quick Details

Port: shanghai port
Payment Terms: T/T,Western Union,MoneyGram
CAS No.: 1270138-40-3
Other Names: NSI-189
MF: C22H30N4O
EINECS No.: N/A
Place of Origin: Hubei China
Type: Central Nervous System Agents,Nootrpics
Grade Standard: Medicine Grade,Tech Grade
Usage: Animal Pharmaceuticals
Brand Name: HHD
Purity: 99%
Product name: NSI-189
CAS: 1270138-40-3
Specification: 99% min
Molecular formula: C22H30N4O
Molecular Weight: 366.4998
Storage: cool and dried place
Shelf life: 2 Years Proper Storage
Application: Anti-Hair Loss
Product Description


Product name: NSI-189

Specification: 99%

CAS No.: 1270138-40-3

Appearance: white powder

Molecular Formula: C19H23N3O3


Usage: Brain Enhancement

NSI-189 is a benzylphiperizine-aminiopyridine, nootropic and neurogenic research chemical created by Neuralstem, Inc. that was derived from pyrazine and nicotinamide. Studies have shown that it stimulates neurogenesis of human hippocampus-derived neural stem cells in vivo and vitro. In healthy adult mice, NSI-189 has been shown to increase the hippocampal volume by 20% and reverse behavioral symptoms in mouse depression models, meaning at the source it could address depression. The hippocampus is responsible for spatial navigation, along with the consolidation of information from short-term memory to long-term memory.

The chemical entity stimulates new neuron growth in the hippocampus, which is an area of the brain that is believed to be contributory in conditions such as post-traumatic stress disorder (PTSD), Alzheimer's disease, and major depressive disorder (MDD).

Function


Tests have shown that NSI-189 significantly improved behavioral responses that are associated with depression . In humans it may counter hippocampal atrophy which is seen in disorders such as MDD, reversing their symptoms. A phase 1B randomized, double-blind, placebo-controlled, multiple-dose escalation study conducted over a 28 day period showed behavioral efficacy in 24 patients who were orally administered NSI-189 . The efficacy measurements showed a clinically meaningful reduction in cognitive and depressive symptoms across all measures, and appeared to persist over time during follow up for the efficacy assessments which included the Clinical Global Impression – Improvement (CGI-I), Montgomery-Aserb Depression Rating Scale (MADRS), Cognitive and Physical Functioning Questionnaire (CPFQ, and the Symptoms of Depression Questionnaire (SDQ).

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Company Introduction
Wuhan Hengheda Pharm Co., Ltd. is a hi-tech enterprise located in Wuhan Private Science and Technology Park, specializing in custom synthesis, manufacture and import & export of fine chemicals, APIs and pharmaceutical intermediates. Hengheda Pharm has complete administration management and a good work team, which makes us grow fast in chemicals and pharmaceutical industry.Hengheda Pharm has a novel R&D center with advanced ventilation equipment and modern experiment equipment. We offer friendly working environment and have skilled people with rich experience in various kinds of experiments and talent chemists professional in R&D and QC. All of these make us provide good quality products with high rating.Hengheda Pharm follows the principle of "quality first, customer above and credit fundamentality", wishing to offer the best products to our customers.
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