Pure Exemestane factory directly sale in stock with resend policy

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Company Information

Guangzhou Longfine Biotechnology Co., Limited

CN Manufacturer, Trading Company, Distributor/Wholesaler
Response Time
<24h
Response Rate:
95.7%
Transactions
US$ 190,000+
6 Years Paid Supplier Gold Supplier Onsite Check Trade Assurance
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Quick Details

Port: Guanzghou/Shenzhen
Payment Terms: T/T,Western Union,MoneyGram,Paypal
Supply Ability: 100 Kilometer/Kilometers per Month Exemestane
Other Names: Exemestane, Exemestane powder, Exemestane intermediate
Usage: Animal Pharmaceuticals
Place of Origin: Guangdong China
Grade Standard: Medicine Grade
Exemestane Appearance: White Powder
Purity: 99%min
Model Number: Exemestane powder
CAS No.: 107868-30-4
Brand Name: Longfine
Type: Antineoplastic Agents,Auxiliaries and Other Medicinal Chemicals
Exemestane Name: aromasin
EINECS No.: 107868-30-4
MF: C20H24O2
Exemestane Shelf life: 3 years
Exemestane Molecular Weight: 296.4 g/mol
Exemestane Usage: Exemestane is an Aromatase Inhibitor
Delivery Detail: Shipped in 2 days after payment
Packaging Detail: Inner PP bag + Outer Al foil bag/tin/drum We can change some conditions according to client's request.

Pure Exemestane factory directly sale in stock with resend policy

 

Chemical information
Molecular Weight296.4Storage3 years -20°C powder
FormulaC20H24O22 years -80°C in solvent
CAS No.107868-30-4SynonymsAromasin
Solubility (25°C) *In vitroDMSO54 mg/mL (182.18 mM)
Ethanol15 mg/mL (50.6 mM)
Water<1 mg/mL
In vivo  
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Longfine tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Purity & Quality

 


 Exemestane Purity(HPLC):   99.5% Exemestane Identity (NMR):    Consistent with structure

 

 

HPLC spectrum of Exemestane

 

S119602-Exemestane-HPLC-Selleck.png

 

Proton NMR Spectrum of Exemestane

S119602-Exemestane-NMR-Selleck.png

Biological Activity
Description

Exemestane is an aromatase inhibitor, inhibits human placental and rat ovarian aromatase with IC50 

of 30 nM and 40 nM, respectively.

In vitro

Exemestane competitively inhibits and time-dependently inactivates of human placental aromatase

 with Ki of 4.3 nM. Exemestane displaces [3H]DHT from rat prostate androgen receptor with IC50 

of 0.9 μM. Exemestane (1 μM) increases alkaline phosphatase activity in hFOB and Saos-2 cells and

 induces the expression of MYBL2, OSTM1, HOXD11, ADCYAP1R1, and glypican 2 in hFOB cells. 

Exemestane causes aromatase degradation in a dose-responsive manner in MCF-7aro cells. 

In vivo

Exemestane increases lumbar spine BMD by 14.0% in OVX rats at dose of 100 mg/kg. Exemestane 

(100 mg/kg) and 17-hydroexemestane (20 mg/kg) significantly reduces an ovariectomy-induced 

increase in serum pyridinoline and serum osteocalcin in rats and causes significant reductions

 of serum cholesterol and low-density lipoprotein cholesterol inOVX rats. Exemestane 

(20 mg/kg/day s.c.) induces 26% complete (CR) and 18% partial (PR) tumor regressions in rats with 

7,12-dimethylbenzanthracene (DMBA)-induced mammary tumors. 

Features17-hydroexemestane is the principal metabolite of Exemestane. 
 
 
Why choose us

 supply Quinine Base (Quinine Anhydrous) powder for soda drinks

 

1)Rapid response R&D group-Guangzhou R&D Center.


2)Experienced production group- Delicacy Management and experienced production mangers in Hubei factory.


3)Well-appointed equipped facility- High pressure hydrogenation, oxidation reaction, Low Temperature Reaction and almost all other reactions could be performed in the factory.


4)Strict and sound quality management system-Put all the production in the quality management system and service in all respects for the customers.


5)Good credit record- Let customers trust the cooperation of both sides, and Longfine always response for his promise.

 

 

Buying Guides

 supply Quinine Base (Quinine Anhydrous) powder for soda drinkssupply Quinine Base (Quinine Anhydrous) powder for soda drinks

 

you can track the shipping situation , you can check courier updating in express web.

 

We can tell delivery time from my shipping experience:

USA& Canada                                       within      5-6 days   

Sweeden, Netherland , Russia ect Europe                   within     7-8 days   

Australia ,Brazil ,ect South American                         within  6-10days   

Philippine, Indonesia etc Southeast Asia     within    4-5 days 

 

THANK YOU FOR YOUR INQUIRY!!!

 

Buying Guides

 supply Quinine Base (Quinine Anhydrous) powder for soda drinks