| Port: | China main port |
| Payment Terms: | L/C,D/A,D/P,T/T,Western Union,MoneyGram |
| Supply Ability: | 2000 Kilogram/Kilograms per Month |
| Other Names: | SIDANAFIL |
| Place of Origin: | China |
| Molecular Weight: | 474.576 |
| Grade Standard: | Medicine Grade |
| Product Name: | Sildenafil powder |
| Purity: | 99% |
| Shelf life: | 2 Years |
| Grade: | Phamaceutical Grade |
| Model Number: | / |
| Appearance: | White Crystalline Powder |
| CAS No.: | 139755-83-2 |
| Brand Name: | Virgin |
| Assay: | 99%min |
| Type: | Auxiliaries and Other Medicinal Chemicals |
| Test Method: | HPLC |
| CAS: | 139755-83-2 |
| EINECS No.: | / |
| MF: | C22H30N6O4S |
| Molecular Formula: | C22H30N6O4S |
| Certificate: | ISO9001 |
| Packaging Detail: | 1kg/bag (Inner: plastic bag .outer: Aluminum foil bag ); 5kg/carton (Inner: Double plastic bags. Outer: Carton); 10kg/carton (Inner: Double plastic bags. Outer: Carton); 25kg/drum (Inner: Double plastic bags. Outer: Fiber drum); Others: According to customer demand. Cool and dry place, keep away from strong light |
| Package Preview: | https://sc04.alicdn.com/kf/H8d1fbd9203e64a839e00646f6558296cG.jpg_640x640.jpg |
GMP Factory Supply API raw material sildenafil powder for sex enhance CAS 139755-83-2
Sildenafil is in a class of medications called phosphodiesterase (PDE) inhibitors. Sildenafil treats erectile dysfunction by increasing blood flow to the penis during sexual stimulation. This increased blood flow can cause an erectction. Sildenafil treats PAH by relaxing the blood vessels in the lungs to allow blood to flow easily. Sildenafil relaxes muscles found in the walls of blood vessels and increases blood flow to particular areas of the body. Another function is used to treat pulmonary arterial hypertension and improve exercise capacity in men and women.
This product is an oral medication for penile erectile dysfunction (ED). It is a citrate of sildenafil, a selective inhibitor of type 5 phosphodiesterase (PDE5) specific to cyclic guanosine monophosphate (cGMP).
Mechanism of action: The physiological mechanism of penile erection involves the release of nitric oxide (NO) in the penile sponge during sexual stimulation. NO activates guanylate cyclase, resulting in increased levels of cyclic guanosine monophosphate (cGMP), which relaxes the smooth muscles in the sponge and fills the blood. Pharmacodynamics Sildenafil's effect on penile erection: Sildenafil is a highly selective phosphodiesterase 5 (PDE5) inhibitor. PDE5 is highly expressed in the corpora cavernosa and in other tissues. (Including platelets, blood vessels and visceral smooth muscle, skeletal muscle), low expression. Sildenafil selectively inhibits PDE5, enhances the nitric oxide (NO) -cGMP pathway, increases cGMP levels and causes smooth muscle relaxation of the cavernous body of the penis, making patients with erectile dysfunction have a natural erectile response to sexual stimulation. Erectile response generally increases with increasing sildenafil dose and plasma concentration. Experiments show that the effect lasts up to 4 hours, but the response is weaker than that at 2 hours. Sildenafil's response to the myocardium: PDE5 does not exist in normal or diseased cardiac conductive tissues, cardiomyocytes, endothelial cells, and lymphoid tissues, so sildenafil (PDE5 inhibitors) have no positive inotropic effect and cannot Directly affect myocardial contractility.
